Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

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Trypanosomes evade the immune response Wireless/IP through antigenic variation of a surface coat containing variant surface glycoproteins (VSG).They also express invariant surface glycoproteins (ISGs), which are less well understood.Here, Macleod et al.

show that ISG65 of T.brucei is Refurbished Grinder a receptor for complement component 3.They provide the crystal structure of T.

brucei ISG65 in complex with complement C3d and show evidence that ISG65 is involved in reducing trypanosome susceptibility to C3-mediated clearance in vivo.